| 产品详情 |
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| Product Name | Ack1 Inhibitor, AIM-100 |
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| Description | Purity ~98% (Chiral HPLC). A cell-permeable furopyrimidine that acts as a potent, ATP-binding site-targeting, Ack1-selective inhibitor (IC50 = 22nM) and effectively prevents receptor-mediated Ack1 activation (by >90% in MEF & LAPC4 cultures; 16h 800nM), while exhibiting much reduced potency against Lyn, Lck, Abl1 and BTK (IC50 ≥346.7nM) and no inhibitory activity toward 25 other kinases. Shown to completely inhibit EGF-induced, but not androgen DHT- (dihydrotestosterone) stimulated, AR transcription activity in serum- and androgen-deprived prostate cancer LAPC4 cutlures. Effectively inhibits androgen-independent LNCaP prostate cancer growth both in vitro (by 60%; 72h 8uM) and in castrated mice in vivo (4mg/kg/96h injections on day 7/11/15/19/23/27 post tumor transplant). Formula: C23H21N3O2 Solubility: DMSO Primary Target: Ack1 Primary Target IC50: 22nM for Ack1 Secondary Target: Lck, Lyn Molar Mass: 371.4 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Ack1 Inhibitor, AIM-100 (Activated Cdc42 Kinase 1 Inhibitor, (S)-5,6-Diphenyl-N-((tetrahydrofuran-2-yl)methyl)furo[2,3-d]pyrimidin-4-amine) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217139 |
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| Order / More Info | Ack1 Inhibitor, AIM-100 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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