| 产品详情 |
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| Product Name | ACK, Recombinant, Human, GST-tag |
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| Description | Purified (~70-90%). ACK is a tyrosine kinase that binds CDC42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of CDC42Hs. Overexpression of ACK in cancer cell lines of epithelial origin increases cellular motility and invasiveness. In a mouse model, ACK overexpression enhances the ability of a human breast cancer cell line to metastasize to the lung and increased mortality. Ligand stimulation of alpha-3 beta-1 integrin leads to activation of ACK which then enhances p130CAS phosphorylation and activation of RAC. Source: Recombinant protein corresponding to human ACK fused to GST-Tag expressed in Insect cells. Molecular Weight: ~66kD Specific Activity: 20nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ACK, Recombinant, Human, GST-Tag (TNK2, ACK1, Activated CDC42 kinase 1, Tyrosine Kinase, Non-receptor 2, Tyrosine Kinase Non-receptor Protein 2, p21cdc42Hs) |
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| Gene, Accession, CAS # | Accession: NM_005781 |
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| Catalog # | 499762 |
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| Order / More Info | ACK, Recombinant, Human, GST-tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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