| 产品详情 |
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| Product Name | ATIC Dimerization Inhibitor |
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| Description | Purity ~97% (HPLC). A cell-permeable dipeptide that reversibly blocks the homodimerization of aminoimidazole carboxamide ribonucleotide transformylase/inosine nomophosphate cyclohydrolase (ATIC) and inhibits its activity (Ki = 691nM, Kd = 240nM). AITC is a bifunctional enzyme that catalyzes the last two steps of de novo purine biosynthesis. Increases the intracellular levels of AICAR leading to the activation of AMP-activated protein kinase (AMPK). Shown to reduce cell viability in a dose-dependent manner. Exhibits a longer half-life and sustained AMPK activation (~ 24h) compared to AICA-riboside. Sequence: Ac-Arg-Ph(4-NO2)-NEt2 Solubility: DMSO Primary Target: ATIC Primary Target Ki: 691nM |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ATIC Dimerization Inhibitor (Ac-Arg-Ph(4-NO2)-NEt2, ATIC Inhibitor, AICAR Tfase Inhibitor, AICAR Transformylase Inhibitor, AICAR Tranformylase/Inosine Monophosphate Cyclohydrolase Dimerization Inhibitor, AMPK Signaling Activator XI) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217196 |
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| Price | |
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| Order / More Info | ATIC Dimerization Inhibitor from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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