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| Product Name | PDK1, Recombinant, Human, HIs-tag |
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| Description | Purified (~70-90%). PDK1 (3-phosphoinositide-dependent protein kinase) is activated by the presence of PtdIns(3,4,5)P3 or PtdIns(3,4)P2. PDK1 then activates protein kinase B (PKB) which, in turn, inactivates glycogen synthase kinase-3 (GSK3). The phosphorylation of other proteins by PKB and GSK3 is likely to mediate many of the intracellular actions of insulin. Thus, PDK1 plays a key role in mediating many of the actions of the second messenger(s) PtdIns(3,4, 5)P3 and/or PtdIns(3,4)P2. The human PDK1 is a 556-residue monomeric enzyme comprising of a catalytic domain that is most similar to the PKA, PKB and PKC subfamily of protein kinases. Source: Recombinant protein corresponding to human PDK1, fused to His-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~67kD Specific Activity: 118nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PDK1, Recombinant, Human, HIs-Tag (3-Phosphoinositide-Dependent Protein Kinase, PRO0461, PDPK1, PkB-Like, PkB-Like 1) |
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| Gene, Accession, CAS # | Accession: NM_002613, SwissProt: O15530 |
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| Catalog # | 500355 |
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| Order / More Info | PDK1, Recombinant, Human, HIs-tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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