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| Product Name | CD105, Recombinant, Human |
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| Description | Purity ≥ 90%. Analysis by RP-HPLC. Chromatographically purified. On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 43kD. CD105 (26-176 a.a.) or Endoglin or GP160 is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. It exists as an O- and N-glycosylated homodimer of 180kD. Up-regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation-associated endothelial cell marker. Endoglin has been found to be part of the TGF-beta1 receptor complex. It thus may be involved in the binding of TGF-beta1, TGF beta3, activin-A, BMP-2, and BMP-7. CD105 binds to TGF Beta1 and Beta3 with high affinity but not TGF-Beta2Beside TGF-beta signaling endoglin may have other functions. It has been postulated that endoglin is involved in the cytoskeletal organization affecting cell morphology |
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| Size | 2ug, 5ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CD105, Recombinant, Human (Endoglin, gp160, TGF beta1,3 Receptor, ENG, END, ORW, HHT1, ORW1, FLJ41744) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | C2446-50R |
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| Order / More Info | CD105, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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