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| Product Name | CD163, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE) under reducing conditions and visualized by silver stain. Endotoxin ≤ 1EU. CD163, previously called M130 or p155, is a 130-160kD type I transmembrane glycoprotein that belongs to group B of the cysteine-rich scavenger receptor family (1-3). It is essential for clearance of hemoglobin-haptoglobin (Hb-Hp) complexes in the liver, spleen and circulation (4). The human CD163 contains a 41 amino acid (aa) signal sequence, a 1009 aa extracellular domain (ECD) with 9 scavenger receptor cysteine-rich (SRCR) domains, a 22 aa transmembrane segment, and a 39-84 aa cytoplasmic region (1). The third SRCR domain is crucial for calcium-dependent binding of hemoglobin/haptoglobin complexes (3). Three splice forms (isoforms 2, 3 and 4) vary within their intracellular regions (1, 5), while one isoform (# 4) also has a 34 aa insert between SRCR domains 5 and 6 within the ECD. While all are expressed, isoform 3 is most abundant, being generally expressed on the cell surface and most |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CD163, Recombinant, Human (Hemoglobin/Haptoglobin Complex Receptor, M130 antigen, Ber-Mac3, Ki-M8, SM4) |
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| Gene, Accession, CAS # | Accession: CAA80543 |
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| Catalog # | C2548-90E |
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| Order / More Info | CD163, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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