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| Product Name | CD22, Recombinant, Human |
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| Description | Purity ~98% (SDS-PAGE and HPLC). CD22 is a B-lineage restricted 135kD glycoprotein whose cell surface expression is limited to resting and activated B lymphocytes. The physiological role of CD22 is still unknown. Targeted disruption of CD22 in mice results in a reduced level of surface IgM on peripheral B cells suggesting a role for CD22 in limiting antigen receptor signaling. CD22 is a member of the Ig gene superfamily that uniquely binds a sialic acid-dependent ligand. Recombinant human CD22 is a soluble 75kD protein which corresponds to the extracellular domain of CD22. Source: Recombinant protein corresponding to human CD22, expressed in CHO cells. Biological Activity: Biological activity was determined by its ability to inhibit the proliferation of Raji cells. The expected ED50 for this effect is 10-17ug/ml. Endotoxin: <0.1ng/ug (1EU/ug) AA Sequence: SKWVFEHPET LYAWEGACVW IPCTYRALDG DLESFILFHN PEYNKNTSKF DGTRLYESTK DGKVPSEQKR VQFLGDKNKN CTLSIHPVHL NDSGQLGLRM ESKTEKWMER IHLNVSERPF |
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| Size | 5ug, 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CD22, Recombinant, Human (B Cell Receptor CD22 Precursor, B Lymphocyte Cell Adhesion Molecule, BLCAM, CD22 Antigen, Leu14, Lyb8, Sialic Acid Binding Immunoglobulin-like Lectin 2, Siglec 2) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 149572 |
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| Order / More Info | CD22, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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