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| Product Name | SETD6, Active |
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| Description | Full length. MW: 75 kDa. Description: Recombinant full-length human SETD6 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: SET domain-containing protein 6 (SETD6) is a mono-methyltransferase that has been shown to methylate RelA of NF-kappa-B complex and thus attenuate NF-kappa-B transcription factor activity. In addition, it monomethylates the histone H2A variant H2AZ which is required for the maintenance of embryonic stem cell self-renewal |
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| Size | 0.005 mg, 0.01 mg |
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| Concentration | n/a |
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| Applications | Methyltransferase Assay |
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| Other Names | [Homo sapiens SET domain containing 6 (SETD6), transcript variant 1, mRNA; N-lysine methyltransferase SETD6; N-lysine methyltransferase SETD6; SET domain containing 6; SET domain-containing protein 6] |
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| Gene, Accession, CAS # | SETD6, Gene ID: 79918, Accession: NM_001160305.2 |
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| Catalog # | MBS515683 |
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| Order / More Info | SETD6, Active from MYBIOSOURCE INC. |
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| Product Specific References | 1. Levy D, et al: Lysine methylation of the NF-kappaB subunit RelA by SETD6 couples activity of the histone methyl-transferase GLP at chromatin to tonic repression of NF-kappaB signaling. Nat Immunol. 2011 12 (1):29-36. 2. Binda O, et al: SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal. Epigenetics. 2013 8 (2):177-83. |
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