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| Product Name | Rac1 Activation Assay |
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| Description | Background: Small GTP-binding proteins (or GTPases) are a family of proteins that serve as molecular regulators in signaling transduction pathways. Rac1, a 21 kDa protein, belongs to the family of Rho GTPases regulates a variety of biological response pathways that include cell motility, cell division, gene transcription, and cell transformation. Like other small GTPases, Rac1 regulates molecular events by cycling between an inactive GDP-bound form and an active GTP-bound form. In its active (GT |
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| Size | 5 assays, 20 assays, |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | MBS168692 |
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| Order / More Info | Rac1 Activation Assay from MYBIOSOURCE INC. |
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| Product Specific References | 1. Raftopoulou M., and Hall A. (2004) Dev Biol. 265: 23-32.2. Bar-Sagi D., and Hall A. (2000) Cell 103: 227-38.3. Benard, V., Bohl, B. P., and Bokoch, G. M. (1999) J. Biol. Chem. 274, 13198-13204.1. Watson, I. R. et al. (2014). The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF. Cancer Res. 74:4845-4852. 2. Yoo, T. H. et al. (2014). Sphingomyelinase-like phosphodiesterase 3b expression levels determine podocyte injury phenotypes in glomerular disease. J Am Soc Nephrol. 10.1681/ASN.2013111213.3. Yanagishita, T. et al. (2014) Actin-binding protein, espin: a novel metastatic regulator for melanoma. Mol. Cancer Res. 12:440-446.4. Tsukamoto, Y. et al. (2013). A Novel Heart Failure Mice Model of Hypertensive Heart Disease by Angiotensin II Infusion, Nephrectomy, and Salt Loading. Am J Physiol Heart Circ Physiol. 305:H1658-H1667.5. Cristante, E. et al. (2013). From the Cover: Feature Article: Identification of an Essential Endogenous Regulator of Blood-Brain Barrier Integrity, and its Pathological and Therapeutic Implications. PNAS. 110:832-841.6. Zhang, L. et al. (2012). A Novel Role of Sphingosine 1-Phosphate Receptor S1pr1 in Mouse Thrombopoiesis. J. Exp. Med. 209: 2165-2181.7. Richier, L. et al. (2010). NOS1AP associates with scribble and regulates dendritic spine development. J. Neurosci. 30:4796-4805.8. Takano, A. et al. (2009). Identification of nectin-4 oncoprotein as a diagnostic and therapeutic target for lung cancer. Cancer Res. 69:6694-6703.9. Shen, E. et al. (2009). Rac1 is required for cardiomyocyte apoptosis during hyperglycemia. Diabetes 58:2386-2395.10. Lise, M-F. et al. (2009). Myosin-Va-interacting protein, RILPL2, controls cell shape and neuronal morphogenesis via Rac signaling. J. Cell Sci. 122:3810-3821.11. Biname, F. et al. (2008). Transforming growth factor beta controls the directional migration of hepatocyte cohorts by modulating their adhesion to fibronectin. Mol. Biol. Cell 19:945-956.12. Zhan, L. et al. (2008). Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma. Cell 135(5):865-878.13. Leung, W. et al. (2007). The Inositol 5'-Phosphatase SHIP-2 Negatively Regulates IgE-Induced Mast Cell Degranulation and Cytokine Production. J. Immunol. 179:95-102.14. Sturrock, A. et al. (2007). Nox4 mediates TGF-b1-induced retinoblastoma protein phosphorylation, proliferation and hypertrophy in human airway smooth muscle cells. Am. J. Physiol Lung Cell Mol Physiol 292(6):L1543-L1555.15. Fan, T-C. et al. (2007). A heparan sulfate-facilitated and raft-dependent macropinocytosis of eosinophil cationic protein. Traffic 8(12):1778-1795.16. Somervaille, T. et al. (2006). Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia. Cancer Cell 10:257-268. |
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