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| Product Name | Compound E, gamma-Secretase Inhibitor XXI |
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| Description | Purity ~95% (HPLC). A cell-permeable, potent, selective, peptidomimetic, non-transition-state analog inhibitor of g-secretase and Notch processing (IC50=300pM for Ab40 in CHO cells overexpressing wild type bAPP; 240pM for Ab40, 370pM for Ab42, and 320pM for NICD, respectively, in HEK293 cells stably transfected with bAPP695 and mNotch deltaE(M1727V); 100pM for both Ab40 and Ab42 in SH-SY5Y cells stably transfected with SPA4CT). Lowers Ab levels in several APP transgenic mouse models. Reported to bind to presenilins and suppress the proteolytic cleavage of transmembrane protein substrates, including APLP1 and APLP2, CD44, ErbB4, E-cadherin, low density lipoprotein receptor-related proteins, Notch ligands, and p75NTR. Only weakly affects presenilinase activity at much higher concentrations, 200-400uM. Formula: C27H24F2N4O3 Primary Target: g-secretase and Notch processing Ab40 in CHO cells overexpressing wild type bAPP Primary Target IC50: 300pM Secondary Target: 240pM for Ab40, 370pM for |
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| Size | 500ug, 1mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Compound E, gamma-Secretase Inhibitor XXI ((S,S)-2-[2-(3,5-Difluorophenyl)-acetylamino]-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-propionamide) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217280 |
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| Order / More Info | Compound E, gamma-Secretase Inhibitor XXI from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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