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| Product Name | COMT, Recombinant, Human, His-Tag (Catechol-O-methyltransferase) |
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| Description | Purity ~90% (SDS-PAGE). Catechol-O-methyltransferase (COMT) catalyzes the transfer of the methyl group from S- adenosyl-L-methionine to either the meta- or the para-hydroxyl group of the catechol ring from a variety of endogenous and exogenous catechol substrates including the neurotransmitters dopamine, epinephrine, and norepinephrine (1). Thus, it plays important roles in one of the major degradative pathways of the catecholamine transmitters, and in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson's disease. In tissues, COMT is produced as two distinct forms, a soluble protein (residues 52-271) and a membrane-bound protein that possesses the N-terminal transmembrane domain (2). A common single-nucleotide polymorphism results in substitution of methionine for valine at position 158 of membrane-bound COMT and position 108 at soluble COMT (3). This amino acid change results in a more unstable and three- to four -fold less active 108/158Met f |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 145784 |
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| Order / More Info | COMT, Recombinant, Human, His-Tag (Catechol-O-methyltransferase) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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