| 产品详情 |
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| Antigenic Specificity | JAK1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | immunogen affinity purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit polyclonal to JAK1. JAK1 (JANUS KINASE 1) is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. JAK1 is a member of a new class of PTKs that are a large family of proteins characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain-hence the name Janus. The JAK1 gene is mapped to 1p31.3. JAK1 is also important for transducing a signal by type I (IFN-alpha/beta) and type II (IFN-gamma) interferons, and members of the IL-10 family via type II cytokine receptors. Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Loss of Jak1 is lethal in neonatal mice, possibly due to difficulties suckling. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body. |
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| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human JAK1, identical to the related mouse and rat sequences. |
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| Other Names | JAK-1, JTK3, JAK1A, JAK1B, Janus kinase 1 |
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| Gene, Accession # | UniProt: P23458 |
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| Catalog # | orb137980 |
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| Price | |
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| Order / More Info | JAK1 Antibody from BIORBYT LTD. |
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| Product Specific References | n/a |
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