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| Product Name | SFRP1, Recombinant, Human |
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| Description | Purity ~97% (SDS-PAGE and HPLC). Secreted Frizzled Related Proteins (sFRPs) modulate WNT signaling by binding directly to WNT proteins in a manner that affects their receptor binding and signaling capabilities. sFRP-1 is a widely distributed protein that can bind directly to WNT1, WNT2, and possibly other WNT proteins, and generally exerts anti-proliferative effects consistent with activity as a WNT antagonist. It also inhibits apoptosis and has been found to be down-regulated in many solid tumors, but up-regulated in uterine leiomyomas. Recombinant human sFRP-1 is a glycosylated 283aa protein containing a cysteine rich Frizzled homologous domain. Source: Recombinant protein corresponding to human Secreted FRP-1, expressed in HeLa cells. Biological Activity: Biological activity was determined by its ability to inhibit BMP-2 proliferation effect of ATDC-5 cells. The expected ED50 is 0.3-0.5ug/ml. Endotoxin: <0.1ng/ug (1EU/ug) AA Sequence: SEYDYVSFQS DIGPYQSGRF YTKPPQCVDI PADLRLCHNV GYKK |
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| Size | 5ug, 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | SFRP1, Recombinant, Human (Secreted Apoptosis-related Protein 2, SARP-2, Secreted Frizzled-related Protein 1, sFRP-1, FRP-1, SARP2, FRP1, FRP) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 149614 |
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| Order / More Info | SFRP1, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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