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RET, Recombinant, Human, GST-Tag (Ret Proto-oncogene, PTC, MTC1, HSCR1, MEN2A, MEN2B, RET51, CDHF12, RET-ELE1) from UNITED STATES BIOLOGICAL |
| 产品详情 |
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| Product Name | RET, Recombinant, Human, GST-Tag (Ret Proto-oncogene, PTC, MTC1, HSCR1, MEN2A, MEN2B, RET51, CDHF12, RET-ELE1) |
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| Description | Purified (~70-90%). RET gene codes for a transmembrane tyrosine kinase which is a subunit of a multimeric complex that acts as a receptor for four structurally related molecules: GDNF, neurturin, artemin and persephin. Germline mutations of RET cause a dominantly inherited dysgenesis of the enteric nervous system known as Hirschsprung's disease. RET is constitutively activated by point mutations in hereditary medullary thyroid carcinomas (MTCs). Several single nucleotide polymorphisms of the RET gene have been described. Multiple endocrine neoplasia type 2A (MEN 2A) have been reported to be associated with two mutations of the protooncogene RET. Source: Recombinant protein corresponding to human RET, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~74kD Specific Activity: 67nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_020630, SwissProt: P07949 |
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| Catalog # | 500421 |
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| Order / More Info | RET, Recombinant, Human, GST-Tag (Ret Proto-oncogene, PTC, MTC1, HSCR1, MEN2A, MEN2B, RET51, CDHF12, RET-ELE1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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