| 产品详情 |
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| Product Name | Piperlongumine |
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| Description | Purity ~97% (HPLC). A cell-permeable, orally bioavailable natural product isolated from the plant species, Piper longum L, which selectively induces cell death in cancer cells that express both wild-type and mutant p53, dose-dependently from 1-15uM, but not in primary normal cells and non-transformed immortalized cells. It significantly enhances wild-type p53 and PUMA expression, and inhibits the expression of several pro-survival proteins, including BCL2, surviving, and XIAP, in various types of cancer cells, but not in normal cells. It elicits ROS and apoptosis in several human cancer cells (EJ, MDA-MB-231, U2OS and MDA-MB-435), possibly through interaction with oxidative stress responders such as GSTP1 and CBR1, and can be reversed by NAC (3mM) in EJ cells. Additionally, it exhibits anti-tumour effects and inhibits the formation of blood vessels in xenograft-tumour mice without obvious toxicity, and inhibits tumor growth and their associated metastases in a MMTV-PyVT breast cancer t |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Piperlongumine (Piplartine, (E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217667 |
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| Order / More Info | Piperlongumine from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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