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| Product Name | TCEA1, Recombinant, Human, aa1-301, His-Tag |
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| Description | Purity ~90% (SDS-PAGE). TCEA1 (Transcription elongation factor A protein 1) belongs to the TFS-II family. TCEA1 binds to Pol II and functions to cleave the nascent transcript, thereby unlocking the complex and allowing transcription to continue. Localized to the nucleus, TCEA1 contains three independently-folding domains, all of which are necessary for proper binding to Pol II. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. Source: Recombinant corresponding to aa1-301 from human TCEA1, fused to His-tag at N-terminal, expressed in E.coli. Molecular Weight: ~36.5kD (325aa) confirmed by MALDI-TOF AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMEDEVV RFAKKMDKMV QKKNAAGALD LLKELKNIPM TLELLQSTRI GMSVNAIRKQ STDEEVTSLA KSLIKSWKKL LDGPSTEKDL DEKKKEPAIT SQNSPEAREE STSSGNVSNR KDETNARDTY |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TCEA1, Recombinant, Human, aa1-301, His-Tag (Transcription Elongation Factor A Protein 1, Transcription Elongation Factor S-II Protein 1, Transcription Elongation Factor TFIIS.o, GTF2S, TFIIS) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 45468 |
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| Order / More Info | TCEA1, Recombinant, Human, aa1-301, His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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