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| Product Name | Reelin, Recombinant, Mouse (BSA Free) |
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| Description | Purity ≥85%, as determined by SDS-PAGE and visualized by silver stain. Endotoxin: ≤0.1EU/ug (LAL). Reelin is a 400kD modular glycoprotein that is critical in brain development and function(1). Reeler mutant mice have a Reelin deficiency and exhibit ataxia, tremors, and impaired motor coordination (2, 3). Reelin consists of an N-terminal Reelin domain, eight domains that consist of an EGF-like repeat flanked by two subrepeats, and a C-terminal arginine-rich region (2). Reelin is cleaved into three fragments in vivo by metalloproteases (4). One (or central) fragment includes domains # 3-6 and retains many of the capabilities of the full length molecule (5). Within this fragment, mouse Reelin shares 95% and 97% aa sequence identity with human and rat Reelin, respectively. In addition to being a protease substrate, Reelin itself has serine protease activity (6). Reelin forms disulfide-linked homodimers and large noncovalently-linked polymers (7,8). It utilizes VLDLR and ApoE R2 as receptor |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NP_035391 |
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| Catalog # | R1362-05MX |
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| Order / More Info | Reelin, Recombinant, Mouse (BSA Free) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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