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| Product Name | Renin Inhibitor Screening BioAssay™ Kit (Fluorometric) (Angiotensinogenase) |
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| Description | Renin (EC 3.4.23.15), also known as an angiotensinogenase, is an enzyme that participates in the renin-angiotensin system (RAS) which mediates extracellular volume (i.e. blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. An over-active renin-angiotensin system leads to vasoconstriction and retention of sodium and water, causing hypertension. Renin inhibitors are widely used for the treatment of hypertension. Intended Use: For use in the screening potential inhibitors of renin and to characterize/study renin inhibitors. Test Principle: The Renin inhibitor screening BioAssay™ Kit uses a synthetic peptide substrate with a fluorophore (EDANS) at one end and a quencher (DABCYL) at the other end. Renin catalyzes the cleavage of FRET substrate resulting in a product that is detected fluorometrically at Ex/Em = 328/552nm. In the presence of a Renin inhibitor, the rate of hydrolysis of the substrate is decreased. The kit provides a rapid, simple, sensitive, and re |
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| Size | 100 tests |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 220228 |
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| Order / More Info | Renin Inhibitor Screening BioAssay™ Kit (Fluorometric) (Angiotensinogenase) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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