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| Product Name | HMTase Inhibitor VI, BRD4770 |
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| Description | Purity ~98% (HPLC). A cell-permeable analog of the amino-benzimidazolo BIX-01338 and the methylester prodrug of BRD9539 that acts as an SAM-competitive inhibitor against PRC2 and G9a (IC50<6.3uM) histone methyltransferase activities, displaying little effect toward 10 other HMTases, 9 HDACs, and 100 cellular kinases. Selectively reduces H3K9me2 and H3K9me3 (EC50=5uM) histone methylation levels in pancreatic cancer cells (PANC-1) with much less or little effect toward H3K36me3, H3K4me3, H3K27me3, or H3K6me3 levels. Inhibits both anchorage-dependent and -independent PANC-1 proliferation via ATM activation and G2/M cell-cycle arrest, but not apoptosis induction (no caspase3/7 activation; 10uM, 72h). Formula: C25H23N3O3 Primary Target: G9a and PRC2 HMTases Solubility: DMSO Molecular Weight: 413.5 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | HMTase Inhibitor VI, BRD4770 (Methyl-2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217436 |
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| Order / More Info | HMTase Inhibitor VI, BRD4770 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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