| 产品详情 |
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| Product Name | HMTase Inhibitor IX, MM-102 |
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| Description | Purity ~95% (HPLC). A cell-permeable peptidomimetic that prevents MLL1 (Mixed Lineage Leukemia 1) from complex assembling with WDR5 (Trp-Asp Repeat Domain 5), RbBP5 (Retinoblastoma Binding Protein 5), and ASH2L (Absent Small or Homeotic-2-Like) for enhanced H3K4 methyltransferase activity (IC50 = 0.4nM). Shown to reduce HoxA9 and Meis-1 mRNA expression in myeloblasts derived from MLL1-AF9-transduced murine bone marrow cells (50uM for 96 h) and preferentially inhibit the growth of MLL1-AF4-harboring MV4;11 and MLL1-ENL-harboring KOPN8 leukemia cultures (GI50 in 7 days = 25uM) via apoptosis induction, while exhibiting much reduced potency against BCR-ABL-dependent K562 cells (GI50 in 7 days = 84uM). Solubility: DMSO Primary Target: WDR5 Primary Target Ki: 1nM |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | HMTase Inhibitor IX, MM-102 (Histone Methyltransferase Inhibitor IX, MM102, (S)-N-(bis(4-Fluorophenyl)methyl)-1-(2-(2-ethyl-2-isobutyramidobutanamido)-5-guanidinopentanamido)cyclopentanecarboxamide, TFA) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217434 |
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| Order / More Info | HMTase Inhibitor IX, MM-102 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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