| 产品详情 |
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| Product Name | HMTase Inhibitor V, UNC0224 |
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| Description | Purity ~97% (HPLC). A quinazolinamine compound that acts as a potent, reversible and SAM (S-adenosylmethionine) non-competitive inhibitor of methyltransferases G9a (H3K9 HMT/EHMT2; IC50=15nM; =23nM) and GLP (G9a-like protein/EHMT1; IC50=20nM). Displays 1,000-fold greater selectivity for G9a over SET7/9 (H3K4 HMTase), SET8/PreSET7 (H4K20 HMTase), PRMT3 (MTase) and JMJD2E (demethylase), and minimally affects the activities of a broad range of GPCRs, ion-channels and transporters in a 30-target selectivity panel, with the exception of muscarinic M2 receptor and histamine H1 receptors (82% and 31% inhibition at 1uM, respectively). Formula: C26H43N7O2. H2O Molecular Weight: 503.7 |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | HMTase Inhibitor V, UNC0224 (Histone Lysine Methyltransferase Inhibitor V, UNC0224, 7-(3-Dimethylaminopropoxy)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine, H2O) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217435 |
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| Order / More Info | HMTase Inhibitor V, UNC0224 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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