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| Product Name | NEK11, Recombinant, Human, GST-tag |
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| Description | Purified (~70-90%). NEK11 is a member of the NEK family and the protein localizes to the nucleoli where it may function with NEK2A in the S-phase checkpoint. NEK2 phosphorylates NEK11 in its C-terminal autoinhibitory domain and elevates NEK11 kinase activity by dissociating the autoinhibitory domain from the N-terminal catalytic domain. NEK11 protein appears to play a role in DNA replication and response to genotoxic stress. NEK11 activity is activated in HeLa cells treated with various DNA-damaging agents and replication inhibitors. Activation of NEK11 by genotoxic agents is suppressed by inhibitor of ATR/ATM-mediated signalling indicating that NEK11 has a role in S-phase checkpoint downstream of ATR/ATM signalling. Source: Recombinant protein corresponding to human NEK11, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~110kD Specific Activity: 25nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | NEK11, Recombinant, Human, GST-Tag (Serine/Threonine-protein Kinase Nek11, Never in Mitosis A-related Kinase 11) |
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| Gene, Accession, CAS # | Accession: NM_024800 |
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| Catalog # | 500297 |
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| Price | |
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| Order / More Info | NEK11, Recombinant, Human, GST-tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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