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| Product Name | Midkine, active (MDK), Recombinant, Human |
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| Description | Purity ≥97% as determined by SDS-PAGE and HPLC. Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity). (ECO:0000250). Biological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human neutrophils is in a concentration range of 0.1-10ng/ml. |
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| Size | 5ug, 20ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | MK, ARAP, Midgestation and kidney protein, Neurite outgrowth-promoting factor 2, Neurite outgrowth-promoting protein |
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| Gene, Accession, CAS # | MK_HUMAN, SwissProt: P21741 |
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| Catalog # | 348178 |
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| Order / More Info | Midkine, active (MDK), Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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