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| Product Name | sDLL1, Recombinant, Human |
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| Description | Purity ≥95% by SDS-PAGE gel and HPLC analyses. Human sDLL-1 comprises the extracellular signaling domain of DLL1, a member of a structurally-related family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. It is expressed in the heart and pancreas, and to a lesser extent in various other tissues. DLL-1 functions to specifically activate the Notch-1 and Notch-2 receptors. The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. DLL-1 suppresses differentiation of hematopoietic progenitor cells into the B-cell lineage while promoting differentiation to T-cell and NK cell precursors. Recombinant human sDLL-1 is a 57-60kD glycoprotein containing 522aa residues. Biological Activity: Determined by the dose dependent growth suppression of the human acute monocytic leukemia cell line, THP-1. sDLL-1 inhibits the proliferation |
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| Size | 5ug, 25ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | sDLL1, Recombinant, Human (Delta-like Protein 1, Drosophila Delta Homolog 1, Delta1, H-Delta-1, UNQ146/PRO172) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 143306 |
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| Order / More Info | sDLL1, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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