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| Product Name | DHFR, Recombinant, Mouse, aa1-187, His-Tag (Dihydrofolate reductase) |
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| Description | Purity ~95% (SDS-PAGE). Dihydrofolate reductase (DHFR) is a member of the reductase family of enzymes that is ubiquitously expressed in all organisms. DHFR catalyzes the NADPH-dependent reduction of dihydrofolate to tetrahydrofolate, and it is essential for the synthesis of thymidylate, purines and several amino acids. Expression of methotrexate (MTX)- resistant variants of DHFR in normal hematopoietic cells is a potential strategy to permit administration of larger doses of MTX by alleviating drug toxicity in normal cells and tissues that are drug sensitive. Source: Recombinant protein corresponding to aa1-187 from mouse DHFR, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~23.6kD (207aa) Specific Activity: >2000pmol/min/ug, and is defined as the amount of enzyme that converts 1pmole of dihydrofolic acid to tetrahydrofolic acid/minute at pH 6.5 at 25°C. AA |
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| Size | 100ug, 500ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NP_034179 |
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| Catalog # | 351189 |
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| Order / More Info | DHFR, Recombinant, Mouse, aa1-187, His-Tag (Dihydrofolate reductase) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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