| 产品详情 |
| Edit |   |
|---|
| Product Name | NF-κB p65 Blocking Peptide |
|---|
| Description | Highly Purified. Peptide is used to block NF-κB p65 Rabbit mAb reactivity in immunohistochemistry protocols. Transcription factors of the nuclear factor κB (NF-κB)/Rel family play a pivotal role in inflammatory and immune responses (1,2). There are five family members in mammals: RelA, c-Rel, RelB, NF-κB1 (p105/p50) and NF-κB2 (p100/p52). Both p105 and p100 are proteolytically processed by the proteasome to produce p50 and p52, respectively. The p50 and p52 products form dimeric complexes with Rel proteins, which are then able to bind DNA and regulate transcription. In unstimulated cells, NF-κB is sequestered in the cytoplasm by its inhibitory proteins, the IκB's (3-5). NF-κB-activating agents can induce the phosphorylation of IκB's, targeting them for rapid degradation through an ubiquitin-proteasome pathway, releasing NF-κB to enter the nucleus, where it regulates gene expression (6-8). Processing of NF-κB2 p100 is reg |
|---|
| Size | 100ug |
|---|
| Concentration | n/a |
|---|
| Applications | IHC |
|---|
| Other Names | n/a |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | N23042 |
|---|
| Price | |
|---|
| Order / More Info | NF-κB p65 Blocking Peptide from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|