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| Product Name | APRIL, Soluble, Recombinant, Human (A Proliferating-inducing Ligand, TNFSF13, TRDL-1alpha) |
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| Description | Purity ~95% (SDS-PAGE). APRIL, a member of the TNF superfamily, is expressed in monocytes, macrophages, certain transformed cell lines, certain cancers of colon, and lymphoid tissues. APRIL, along with another TNF family member, BAFF, compete for two receptors, TACI and BCMA. ARPIL has the ability to stimulate proliferation of various tumor cell lines including Jurkat T cells and MCF-7 carcinoma cells. Like BAFF, APRIL also stimulates the proliferation of B and T cells. The human APRIL gene codes for at least four alternatively spliced transcriptional variants, which give rise to different isoforms of the APRIL precursor protein. All isoforms can be cleaved by the protease, furin, to release a soluble C-terminal fragment, which comprises the TNF like receptor binding of the APRIL precursor. Source: Recombinant protein corresponding to 146aa residues from soluble human APRIL, expressed in Hi-5 insect cells. Molecular Weight: ~16.3kD Biological Activity: Determined by its ability to indu |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | A Proliferating-inducing Ligand, TNFSF13, TRDL-1α |
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| Gene, Accession, CAS # | APRIL, Gene ID: 8741, Accession: O75888 |
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| Catalog # | 219434 |
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| Order / More Info | APRIL, Soluble, Recombinant, Human (A Proliferating-inducing Ligand, TNFSF13, TRDL-1alpha) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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