| 产品详情 |
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| Product Name | PK11195 |
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| Description | Purity ≥98% (HPLC). An isoquinoline carboxamide that acts as a potent ligand for peripheral bezodiazepine receptor (Kd = 20nM). Exhibits anti-inflammatory properties. Binds to monocytes and following lesioning its binding up-regulated in brain macrophages and activated microglia. Shown to enhance the susceptibility of cells to apoptosis induction by DNA damaging agents and can reverse the suppression of apoptosis by Bcl-2. Serves as a ligand of the outer membrane translocator protein and reduces mitochondrial transmembrane potential within 30 minutes of exposure (?100uM). Synonyms: TSPO Activator II, Mitochondrial Translocator Protein Activator II, PK 11195, PK-11195, PK11195 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TSPO Activator II, Mitochondrial Translocator Protein Activator II, PK 11195, PK-11195, PK11195 Molecular Formula: C??H??ClN?O Solubility: DMSO Primary Target: peripheral bezodiazepine receptor Primary Target Ki: 20nM Molecular Weight: 352.86 Appearance: Supplied as a white solid. Purity: ≥98% (HPLC) Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217669 |
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| Order / More Info | PK11195 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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