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| Product Name | UBE2K, Recombinant, Human, aa2-200, His-Tag (Ubiquitin-conjugating Enzyme E2 K) |
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| Description | Purity ~90% (SDS-PAGE). Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In c |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Huntingtin-interacting protein 2, HIP-2 Ubiquitin carrier protein, Ubiquitin-conjugating enzyme E2-25kD, Ubiquitin-conjugating enzyme E2(25K), Ubiquitin-conjugating enzyme E2-25K, Ubiquitin-protein ligase |
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| Gene, Accession, CAS # | SwissProt: P61086 |
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| Catalog # | 375750 |
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| Order / More Info | UBE2K, Recombinant, Human, aa2-200, His-Tag (Ubiquitin-conjugating Enzyme E2 K) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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