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| Product Name | nNOS - PSD-95 Interaction Inhibitor, ZL006 |
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| Description | Purity ~98% (HPLC). A cell-permeable and blood-brain barrier-permeant aminosalicylic acid compound that selectively disrupts nNOS and PSD-95 interaction uponnMDAR activation both in primary murine cortical neurons (0.8- and 2.8-fold increase from basal level with or without 30min 10uM ZL006 pretreatment) in vitro and in mice (0.4- and 1.9-fold increase from basal level with or without inhibitor pretreatment 15min before ischemia; 1.5mg/kg i.v.) in vivo without affecting nNOS activity or non-nNOS-mediatednMDAR EPSCs (excitatory postsynaptic currents). Effectively reduce ischemia-caused brain tissue damage in both mice and rats when applied 1h after blood reperfusion following ishemia (60% and 50% reduction of infarction, respectively; 1.5mg/kg i.v.). Formula: C14H11Cl2NO4 Molecular Weight: 328.2 Solubility: DMSO (50mg/ml) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | nNOS - PSD-95 Interaction Inhibitor, ZL006 (5-(3,5-dichloro-2-hydroxybenzylamino)-2-hydroxybenzoic Acid) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217595 |
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| Order / More Info | nNOS - PSD-95 Interaction Inhibitor, ZL006 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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