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| Product Name | LexA Repressor, Recombinant, E. coli, aa1-202, His-SUMO-Tag (LexA) |
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| Description | Purity ~90% (SDS-PAGE). Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment. The SOS response controls an apoptotic-like death (ALD) induced (in the absence of the mazE-mazF toxin-antitoxin module) in response to DNA damaging agents that is mediated by RecA and LexA. Source: Recombinant protein corresponding to aa1-202 from E. coli lexA, fused to His-SUMO-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~38.4kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P0A7C2 |
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| Catalog # | 374013 |
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| Order / More Info | LexA Repressor, Recombinant, E. coli, aa1-202, His-SUMO-Tag (LexA) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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