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| Product Name | PABPC1, Recombinant, Human, aa1-370, His-SUMO-Tag (Polyadenylate-binding Protein 1) |
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| Description | Purity ~90% (SDS-PAGE). Binds the poly(A) tail of mRNA, including that of its own transcript. May be involved in Cytoplasmic domain regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to Cytoplasmic domain RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the Cytoplasmic domain deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. Source: Recombinant protein corresponding to aa1-370 from human PABPC1, fused to His-SUMO-Ta |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P11940 |
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| Catalog # | 374591 |
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| Order / More Info | PABPC1, Recombinant, Human, aa1-370, His-SUMO-Tag (Polyadenylate-binding Protein 1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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